Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists

J Med Chem. 1993 Nov 12;36(23):3734-7. doi: 10.1021/jm00075a032.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzodiazepines / chemical synthesis*
  • Benzodiazepines / metabolism
  • Benzodiazepines / pharmacology
  • Diamines / chemistry*
  • Diamines / pharmacology
  • Guinea Pigs
  • Molecular Structure
  • Muscarinic Antagonists*
  • Rats
  • Receptors, Muscarinic / metabolism
  • Structure-Activity Relationship

Substances

  • Diamines
  • Muscarinic Antagonists
  • Receptors, Muscarinic
  • Benzodiazepines
  • tripitramine
  • methoctramine